I am using Dynamic Sender Profiles in a few Journeys. They're great, but I have a situation where our Booking team would like to update the Booking Manager assigned to an Opportunity after the contact has entered a given email Journey, meaning they would want any personalised emails to come addressed from the newly assigned Booking Manager.
Is this possible to achieve with AMPscript perhaps or does Marketing Cloud not accept "very" dynamic sender profiles? If so, could someone guide me in the right direction on how I can do it?
Mateusz Dąbrowski (mateuszdabrowski.pl) 
Forum Ambassador
It is possible, but depending on your scenario, might be a bit more complicated.
So Dynamic Sender Profile is using an AMPScript value to define the sender, for example:
%%=v(@fromName)=%%
That variable @fromName has to be configured within the email to define what value will be behind it for each subscriber.
So you depending on how dynamic that change has to be, you can either build a lookup to Synchronised Data Extension for Opportunity object or - if the configured refresh schedule is not enough - you can even get the data in real time directly from Opportunity with RetrieveSalesforceObject function.
However, keep in mind that making a call to SF CRM directly will have negative performance impact vs lookup to a table in SFMC.
