Working on using a dynamic sender profile and I am running into some trouble. I currently have a plan to add FromName and FromEmail fields in the data extension and use an IFF statement to reference that data. However, that will require that I download the data extension (~1.5M) records and manually add these. 

My question is, can you use a LOOKUP(IF()) and reference another, smaller DE (300), to fill the FromName and FromEmails in the sender profile?