Hey there,

Here's an article that is a nice overview on how to create a more streamlined feel in Lightning apps for both Blind and Low Vision users. By assigning them to one of two Profiles and then making tweaks in the layouts to cater to the type of users who are in your Org. It's definitely food for thought. 

I personally am a Fusion User (the combination of JAWS, a screen reader for the Blind, with ZoomText, a magnification software for Low Vision) so I would walk the line between the two Profiles. Since I use Fusion I never have my screen zoomed in to 800% for any amount of time because at that point its more efficient to use the JAWS part of Fusion. I had not thought about using the Accordion Component to aid Low Vision Users, it might come in handy in the future where ever my Salesforce path leads me.

I think the biggest take away is the end, "Every user with a disability is going to have their own approach or set of techniques for accessing computers and tools like Salesforce. If you aren’t sure what approach will work best for someone, just ask them. They’ll be glad you did!"

Hopefully this article helps open your eyes with how to better serve these users in your Org!

How to Configure Salesforce for Your Blind and Low Vision Users