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Laura,Permission Sets: In these Permission sets we define the access level of the user. Generally, we determine what a user can do in the applications. These are used to grant additional permission to a user.Profiles: In Object level Security, Profiles are assigned to the user by the system administrator. A profile can be assigned to many users where a user can have only one Profile.The key difference between the two is that the Profile is the user's base set of permissions and all users are assigned to one. ... Profiles can be used to give or take away permission from the users assigned to them. Permission Sets can only give or extend permission to the users assigned to them.I think this a good example to understand better:The profile is like a Key to HousePermission sets are like keys to individual Rooms.So if this profile is assigned to the user means he can enter the house but can’t enter the roomsUntil and unless permission sets are assigned to the user he can't enter the roomsFor further information check the below discussion which has examples too,https://salesforce.stackexchange.com/questions/119220/exclusive-differences-profiles-vs-permission-sets/119297⌗:~:text=The%20key%20difference%20between%20the,users%20are%20assigned%20to%20one.&text=Profiles%20can%20be%20used%20to%20give%20or%20take%20away%20permission,the%20users%20assigned%20to%20it.Let me know if it helps you and close your query by marking it as solved so that it can help others in the future.Thanks.