New org what will you do first?

So you go from one client to another, seeing a new org again and again. What would you do first the make things a little bit easier for yourself?

And also what would you check first?

Things i do when im confronted with a new org (Sandbox)

1. Setup>> Deliverabillity>> Access level:  and change this setting
2. Setup>> Session Settings >> Uncheck "Force relogin after Login-As-User" 
3. ?
4. ?
5. ?